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Have you tried dexamethasone (aka Decadron)? I have some experience with it for an issue similar (but not the same and not as rare) as yours and it was a game-changer.

Did you have a good weekend? I hope you did :)

If you're allergic to water then how do you keep yourself externally hydrated ? Doesn't it causes any kinda of severe infection or How do you deal with it ?

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Have you noticed a difference between different types of water? Like salt water vs. regular water vs. purified etc

Curious. One of the main issues in school is that people are afraid to ask the stupid questions.

Probably better to use Zyrtec or something else, 1st gen antihistamines are not fun over the recommended dose

What about completely purified water, like reverse osmosis, distilled, etc? Is it really the water or is it certain minerals/contaminants in the water?

Do you think you would ever get a tattoo? Would that cause a problem?

You mentioned that you have other rare diseases. Did you ever did a dna test like myheritage or 23andme? I case you did, you can download your raw dna data, reupload it to promethease and get it analysed for free. You might get some interesting insights :) best of luck to you!

Does that make you afraid of water? Or do you accept your fate and go for bath (just like my lactose intolerant friends accept their fate and drink milk)

Have you tried alcohol based wipes?

Have you tried distilled/deminarized water?

Ps: finally found someone who has more strange allergy than me.. I'm allergic to certain light in UV spectrum

That means allergic reaction within minutes of exposure to sun or within hours under certain types of lights

What happens if you drink water?

Is the water reaction same as if you ate something you were allergic to? Does taking antihistaminic meds possibly help or lessen the reaction? Or does any medication help or prevent a reaction or possibly speed up the healing process? I'm also wondering is it the H2O You're allergic to or the minerals that are dissolved in water?

Does increased humidity (like going somewhere tropical or just the micro-environment around your face when your wear a face mask) trigger it?

I have the same condition since i hit puberty. For me it is a autoimmune disease that was triggered by puberty hormones.

I take Rupatadine Pills, so nowadays i hardly notice it anymore. Its specially for chronical urticaria. Maybe you could try it?

This is an excellent question. H20 molecules are incident upon her 24/7, and even in low RH, there is always some condensation that occurs, but if RH < 100% then the rate of condensation < rate of evaporation.

It would totally make sense for some sort of reaction to occur in high RH conditions, where the rate of condensation approaches evaporation.

That's a good intuition, human palms and soles have an extra layer of cells (stratum lucidum.)

> Then, after a few different dermatology/allergist visits, I was formally diagnosed.

No offense, but considering how ridiculously rare this disorder is (like 50 to 100) documented cases... "a few' visits would seem low (ie. Took me "a few" just for a regular allergy panel with treatment, etc)

Have you tried any alternative medicine therapies in addition to your current medications? If yes then which ones?

Does temperature have any effect on the severity? Maybe colder showers lead to fewer hives, and you could get used to them.

Famotidine is an anti-acid/anti-reflux drug (Prilosec is the brand name). Maybe it's loratadine (Claritin) you're thinking of?

Did you scream "For science!" before each test?

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The first conceptual leap is that it seems to be specifically the skin having a reaction to water and not an ingestion intolerance. It still seems wrong because your cells contain water, but the outermost layer of skin is very different from a traditional live cell.

Just some thoughts from a trained biologist who also had the exact same first reaction lol.