Time to block another karma farmer

Technically cancer is your own body fighting against itself.

What company’s drug is this? There was no mention of the name of the company that discovered the drug?

Given the current state of medicine in general and oncology itself, I would not doubt this is possible. Everyday pretty much there are new treatments becoming available and a ton of data is being collected to improve the current state of things.

Glad to hear that. I didn't know that they give sprycel for AML. I have CML, and it's a common treatment for that.

Watch out for pleural effusion. If you have any trouble breathing, let your doctor know asap. Often times a 50mg dose works as well as 100, but without as many side effects.

Hey man, 30% full recovery of 40% of leukemia patients ain’t too bad. 12% of all leukemia patients get a cure. Further 3% get a cure with the medicine + a bone marrow transplant. Those are good numbers compared to 0%

So far so good. I am getting for AML after chemo which seems to be a fairly newish use for it. I have been on it for 6 months and will stay on it for 6 more. Compared to the chemo, Sprycel ain’t bad at all.

Congrats on your remission.

It’s the meat that can’t be beat!

Are custom shoes something that nobody does in the US, but big companies, or are just excessively expensive? Like, shoemaker with their own shop you can go to and have a custom shoe made.

No landlords. No rentals. Sounds like a plan.

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Seems that way because every one of these articles is about a different kind of cancer. Even leukemia has 4 main types with a bunch of variations underneath. Every breakthrough is for a very specific type of cancer. There's no one size fits all "cure for cancer" and I suspect there never will be.

Just some helpful context here for those reading your comment: this trial was done on patient with relapsed AML (it came back after having gone away) or refractory AML (meaning the cancer never actually got to remission). The standard treatment for relapsed/refractory acute leukemia is a bone marrow transplant, which is pretty toxic (more so than most standard chemo). Success rates of transplant are much better if you can get in remission prior to transplant. So having a drug that can help get people into remission is a big step forward.

Regarding the outcomes mentioned, there are many ways to try and measure if someone is in remission. Morphological remission just means when they looked at the bone marrow under the microscope, they didn’t see leukemia cells. The better measure of remission is MRD (Minimal Residual Disease), which is a test using a different method called flow cytometry that looks at individual cells and the markers they produce to find cancer cells. If MRD is negative, that’s considered better than morphological remission.

I was on sprycel as well for a couple years. Made it to treatment free remission after a scary pleural effusion. How's it treating you?

I'm sorry to hear about your father, that's awful.

I've been living with CML since 2007. Today there's are a number of treatments that basically didn't exist before 1999. The breakthrough drug is called Gleevec, and now there are several generations of treatments beyond that. I feel lucky to have been diagnosed when I was. A decade earlier and I there's a good chance I wouldn't be here today.

You must be really fun at parties.

You have one more internet stranger hoping the best for your family.

"Fuck Brandon. We're gonna keep selling off Sam Houston National Forest one parcel at a time to developers" - Greg

I want to add some context to the term complete remission. I was almost killed because of the misunderstanding of it.

In Leukemia, a Complete remission is an outdated metric. Many years ago we had limited ability to detect cancer cells in bone marrow. If you run that test and dont see any cancer cells then it is termed as a complete remission. This sounds wonderful, and many drug companies use this as the basis for their reporting because it makes their drugs look better than they are.

Today, there are tests that can see cancer cells thousands of times better than a complete remission. What we as laymen would call a "complete remission." is actually called MRD negative in leukemia. Any study that does not mention MRD status of the patients is not reporting the full facts and using the term Complete remission as publicity to get investments.

EDIT: since someone pmed me to ask, When I was diagnosed I was given the option of several treatments. The one the doctor wanted me to accept was presented as "99% of patients on this plan have a complete remission in 6months, and it has far less side effects than these other treatments. So obviously I accepted that one. 99% chance of being cancer free? low to no side effects? fuck yeah sign me up doc!

After reading all night I discovered the real terminology in leukemia and found that the treatment I just signed up for had a 99% complete remission rate, but only a 47% MRD negative rate, and a 34% 5 year survivability rate.

While another option had no reported complete remission rate, because its a shitty outdated metric, but had a 88% MRD negative rate, and a 77% 5 year survivability rate.

The option that I was nearly tricked into accepting is far cheaper, and since I had just lost my job (due to being sick.) they were looking to save money.

The other hard part is the pill is the size of a basketball.

Never believe the cancer headlines. They are usually one or more of the following:

1. Hypothetical
2. Misrepresented
3. Not yet tested in humans
4. Years and years away from actual approval

Whinging? Fuckin' awesome! watch a little too much Letterkenney?

The NPS is woefully underfunded no matter how much they have increased the budget. Parks and monuments do not have the personnel or facilities to handle the increased visitors, buildings and infrastructure are in decay. It is pretty apparent if you visit the parks. Park staff do a good job for the resources they have, but staffing parks is getting harder as folks want to realize they want to get paid even for a job they love.

And insurance won't cover it

🏅

Thanks friend… it’s kind of been a big fuck you from life lately but we have lots of family support and doing our best. I just pray it’s not the one two punch that happens sometimes when married couples lose a partner and the other follows shortly after. It’s going to be a rough time either way but there are so many people that have to deal with this - I’m just lucky I’m 38 and I’ve had them in my life that whole time.