Recent comments in /f/explainlikeimfive
cdickerson09 t1_jegg1gg wrote
Reply to ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
Most of them have a really high safety window, so the therapeutic range is large, and hard to go into the toxic range. And unless combined with other substances they don't usually depress your respiratory system.
effrightscorp t1_jegfzyj wrote
Reply to comment by shockencock in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
LD50 is 1850 mg/kg in mice, so it takes around 40 mg to kill an average one. Here's a case study where one guy took 100 mg, one woman took 120 mg and both were out of the hospital within a few days and didn't really need any treatment
You can take stupid big overdoses of benzos and survive because they all have pretty good therapeutic indices. The bigger issue is that, if you don't pass out, you'll probably run out blacked out and can do enough stupid shit to end up in jail etc
shockencock t1_jegfze2 wrote
Reply to comment by Prinzka in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
I guess you are right. Most people that try to kill themselves with it drink alcohol too. I stand corrected. I couldn’t imagine taking 50 mg of it.
frustrated_staff t1_jegfoq7 wrote
Reply to ELI5: How does salt seemingly hydrate you and dehydrate you at the same time. They always say you need electrolytes (salt?) for hydration, then why can’t we drink sea water? by TriCombington
So...you can actually drink sea water (for a limited time) in order to hydrate yourself. The thing is, in quantities high enough to maintain that hydration (as opposed to staving off dehydration), you'd have to drink too much of it over too short a period of time, overloading your kidneys' ability to filter out the excess salt, resulting in hypersalinity. And that's Bad. But, for short periods at the right rate, it is possible.
In the end, it's all about balance: if you go into a situation severely depleted in electrolytes (of which salt is only one option), and drink sea water, it can actually help, up until the balance is restored, and then you start tipping the scales in the other direction.
Homeostasis is key.
Prinzka t1_jegfo73 wrote
Reply to comment by shockencock in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
Lol
Lorazepam has an ld50 of nearly 2g/kg.
That's the whole reason OP made this post, they were wondering why you can take high doses of benzos without dying even though it's a cns depressant.
Kind-Wait-2432 t1_jegfm7i wrote
Reply to comment by [deleted] in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
you can call or chat on 988, anytime
Columbus43219 t1_jegfhzu wrote
Reply to ELI5: How does a DNR work? by HalloweenLover
If you get older and want a DNR, have it tattooed on your forehead! My mom coded after a long fight with SuperNuclear palsey (Dudley Moore) and they grabbed the wrong chart and revived her.
She lived another six months in a vegetative state.
Omniwing t1_jegfdzd wrote
Reply to comment by ejpierle in ELI5: why does the US need the dollar to be the only primary form of currency for oil? by aresyves
We do though. The Nigeria can not buy oil from Saudi Arabia for any currency other than U.S. dollars. So if Nigeria doesn't have dollars, the easiest way to get them is to sell goods to the US for dollars, and then use those dollars to buy oil.
Also, Henry Kissinger went to Saudi Arabia in 1973, and we made a deal with them that they will not sell oil for any other currency other than dollars, and we will make sure the Sauds stay in power in the region and in their kingdom.
This is one way the U.S. holds it's hegemony over the world.
shockencock t1_jegfcqz wrote
Reply to comment by effrightscorp in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
My brother is a psychiatric nurse in a hospital. He would inject 2 mg of lorazepam into patients then put them into seclusion to sleep it off. The starting dose for lorazepam is like .5 mg
Sand_Trout t1_jegfak7 wrote
Reply to comment by Any-Growth8158 in ELI5: What actually happens when you call your representatives? by glitterismyantidrug_
That's what campaign fundraiser dinners are for. Those folks don't call the congressman's publicly listed office phone number.
boshbosh92 t1_jegf7so wrote
Reply to comment by RLDSXD in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
I thought they all got banned? I know etizolam did at least in my state, and the vendor I would buy from is in federal prison right now for misleading customs. I am definitely on a watch list of some sort
carrot_bunny_dildo t1_jegf6eu wrote
Reply to comment by shakn1212 in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
So yeah that’s right. Benzodiazepines (BZD) are ‘allosteric modulators’ they don’t actually bind the GABA receptor site on the BZD receptor. Instead, BZD’s increase the affinity of the neurotransmitter GABA to bind at the BZD receptor. In other words, if there was no GABA neurotransmitters BZD’s would have no effect.
Additionally, administration on BZD causes rapid withdrawal of BZD receptors from the cell surface, which is another reason that likely increases their safety.
ThatsTooOP t1_jegf5x4 wrote
Reply to comment by aresyves in ELI5: why does the US need the dollar to be the only primary form of currency for oil? by aresyves
If you print more marbles in the toy trading game, their value decreases. Similarly, if a country prints more currency for trading, its value decreases, leading to inflation. In the case of oil trading, if the US prints more dollars, the dollar's value may decrease, and other countries may find a different currency to use for oil trading or create their own.
aresyves OP t1_jegf543 wrote
Reply to comment by Loki-L in ELI5: why does the US need the dollar to be the only primary form of currency for oil? by aresyves
Now I understand why they called the dollar a reserve currency. Your response was helpful and also made me think of that board game, Settlers of Catan lol
CorInHell t1_jegf31k wrote
Reply to comment by Trivius in ELI5: How does a DNR work? by HalloweenLover
I'm from europe, so I don't know.
Jkei t1_jegf2d8 wrote
Reply to comment by TaliZorahVasDeferens in ELI5: If Alcohol stimulate opioid receptors, how is it not classified as an opiate? by TriCombington
+1 to well said but dear lord that username
shockencock t1_jegf1ja wrote
Reply to comment by effrightscorp in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
You have it confused with another benzo. 50 mg of lorazepam will kill you in about an hour
Tool_looT t1_jegf131 wrote
Reply to comment by psychrolute in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
Yeah I’ve just recently been clean off Bezos, combined with alcohol or Opiates before that. I was taking around 100mg of Xanax or something close too that everyday. I quit around 5 months now almost dies for second time, the seizures from withdrawal are no joke and I struggled with it for years. Dropped right in front of my folks this time saved my life after the hospital sent me home and told me I wouldn’t have them off just benzos, yeah right. Spent a month in the hospital detoxing and another six weeks in rehab took about 6 weeks of detox too even be myself. Be careful guys!
effrightscorp t1_jegevz4 wrote
Reply to comment by shockencock in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
50 mg lorazepam won't even kill a rat
Trivius t1_jegetej wrote
Reply to comment by CorInHell in ELI5: How does a DNR work? by HalloweenLover
I think it could be a US thing?
Averagebass t1_jeges4x wrote
Reply to comment by congoLIPSSSSS in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
I only did it in one hospital, but it seemed to be as effective as Ativan. I had been in 4 different hospitals and only one of them did it.
boshbosh92 t1_jeges1b wrote
Reply to comment by psychrolute in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
Dude as someone who used to abuse the hell out of etizolam I don't know how you even physically took 950mg.
They came in liek 1-2 MG tablets. I literally remember nothing from the entire year of 2016 from taking 5-8mg of etizolam. I cannot fathom almost a gram. Hope you stopped that stuff and are doing well. It was hard getting off but it's worth it.
aresyves OP t1_jeger9c wrote
Reply to comment by ejpierle in ELI5: why does the US need the dollar to be the only primary form of currency for oil? by aresyves
Yeah I was a little weary of that response too. Only because then wouldn’t other countries start a war with US for blocking oil transactions? Hopefully I understood this correctly
skittlebog t1_jegempw wrote
Reply to comment by Soory-MyBad in eli5: Why do seemingly all battery powered electronics need at least 2 batteries? by OneGuyJeff
Can it be done, yes. Has it been done, yes. Is it worth doing in most cases, no. Lots of devices have been produced that used proprietary batteries. And they are a pain. I had 2 different wireless land line phones that used different battery packs that were basically 2 or 3 batteries wrapped together. I had to special order a new battery each time. It is much simpler to just use multiple standard batteries.
timmmmehh t1_jegg9jx wrote
Reply to comment by dman2316 in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
What ended up happening after being given that much? I would imagine you would be knocked out after that lol.