Recent comments in /f/explainlikeimfive

effrightscorp t1_jegfzyj wrote

LD50 is 1850 mg/kg in mice, so it takes around 40 mg to kill an average one. Here's a case study where one guy took 100 mg, one woman took 120 mg and both were out of the hospital within a few days and didn't really need any treatment

https://ajp.psychiatryonline.org/doi/10.1176/ajp.137.11.1414?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

You can take stupid big overdoses of benzos and survive because they all have pretty good therapeutic indices. The bigger issue is that, if you don't pass out, you'll probably run out blacked out and can do enough stupid shit to end up in jail etc

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frustrated_staff t1_jegfoq7 wrote

So...you can actually drink sea water (for a limited time) in order to hydrate yourself. The thing is, in quantities high enough to maintain that hydration (as opposed to staving off dehydration), you'd have to drink too much of it over too short a period of time, overloading your kidneys' ability to filter out the excess salt, resulting in hypersalinity. And that's Bad. But, for short periods at the right rate, it is possible.

In the end, it's all about balance: if you go into a situation severely depleted in electrolytes (of which salt is only one option), and drink sea water, it can actually help, up until the balance is restored, and then you start tipping the scales in the other direction.

Homeostasis is key.

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Columbus43219 t1_jegfhzu wrote

If you get older and want a DNR, have it tattooed on your forehead! My mom coded after a long fight with SuperNuclear palsey (Dudley Moore) and they grabbed the wrong chart and revived her.

She lived another six months in a vegetative state.

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Omniwing t1_jegfdzd wrote

We do though. The Nigeria can not buy oil from Saudi Arabia for any currency other than U.S. dollars. So if Nigeria doesn't have dollars, the easiest way to get them is to sell goods to the US for dollars, and then use those dollars to buy oil.

Also, Henry Kissinger went to Saudi Arabia in 1973, and we made a deal with them that they will not sell oil for any other currency other than dollars, and we will make sure the Sauds stay in power in the region and in their kingdom.

This is one way the U.S. holds it's hegemony over the world.

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carrot_bunny_dildo t1_jegf6eu wrote

So yeah that’s right. Benzodiazepines (BZD) are ‘allosteric modulators’ they don’t actually bind the GABA receptor site on the BZD receptor. Instead, BZD’s increase the affinity of the neurotransmitter GABA to bind at the BZD receptor. In other words, if there was no GABA neurotransmitters BZD’s would have no effect.
Additionally, administration on BZD causes rapid withdrawal of BZD receptors from the cell surface, which is another reason that likely increases their safety.

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ThatsTooOP t1_jegf5x4 wrote

If you print more marbles in the toy trading game, their value decreases. Similarly, if a country prints more currency for trading, its value decreases, leading to inflation. In the case of oil trading, if the US prints more dollars, the dollar's value may decrease, and other countries may find a different currency to use for oil trading or create their own.

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Tool_looT t1_jegf131 wrote

Yeah I’ve just recently been clean off Bezos, combined with alcohol or Opiates before that. I was taking around 100mg of Xanax or something close too that everyday. I quit around 5 months now almost dies for second time, the seizures from withdrawal are no joke and I struggled with it for years. Dropped right in front of my folks this time saved my life after the hospital sent me home and told me I wouldn’t have them off just benzos, yeah right. Spent a month in the hospital detoxing and another six weeks in rehab took about 6 weeks of detox too even be myself. Be careful guys!

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boshbosh92 t1_jeges1b wrote

Dude as someone who used to abuse the hell out of etizolam I don't know how you even physically took 950mg.

They came in liek 1-2 MG tablets. I literally remember nothing from the entire year of 2016 from taking 5-8mg of etizolam. I cannot fathom almost a gram. Hope you stopped that stuff and are doing well. It was hard getting off but it's worth it.

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skittlebog t1_jegempw wrote

Can it be done, yes. Has it been done, yes. Is it worth doing in most cases, no. Lots of devices have been produced that used proprietary batteries. And they are a pain. I had 2 different wireless land line phones that used different battery packs that were basically 2 or 3 batteries wrapped together. I had to special order a new battery each time. It is much simpler to just use multiple standard batteries.

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